Doctor Lou Fourriere-Chea

University of Melbourne, AUS

Dr Lou Fourriere completed her PhD in 2016 at the Institut Curie (Paris, France) in the laboratory of Franck Perez.

Her research investigated the role of microtubules in intracellular trafficking, particularly membrane trafficking from the Golgi to the cell surface. By using the Retention Using Selective Hooks (RUSH) system, which synchronizes the anterograde trafficking of cargoes in real time, she showed that cargoes are delivered to ‘hot spots’ on the plasma membrane and that microtubules were not strictly essential for cargoes delivery to the surface.

After her PhD, Lou joined the team of Prof Paul Gleeson (Bio21 Molecular Science and Biotechnology Institute, University of Melbourne). Here she is investigating the intracellular trafficking of the beta-secretase (BACE1) and amyloid precursor protein (APP) to characterize their trafficking routes and the machinery regulating these trafficking routes.

Lou is using a range of optical imaging approaches including the RUSH system, spinning disk, TIRF microscopy, and high resolution imaging to track the transport pathways of newly synthesized BACE1 and APP in cells. Her studies have demonstrated the partitioning of BACE1 and APP within the Golgi apparatus, a process which is critical to the regulation of APP processing and amyloid production within the secretory pathway.