Dr. Julia Pagan performed her postgraduate studies in the laboratory of Professor Kum Kum Khanna at the Queensland Institute of Medical Research.
Her post-doctoral work was performed in the Biochemistry Department at New York University Langone Medical Center under the mentorship of Professor Michele Pagano. Here, she studied the molecular and biochemical mechanisms by which cullin-RING ligases (CRLs) [particularly, SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes also known as CRL1s] regulate cell growth and proliferation.
In 2018, she moved to the School of Biomedical Sciences, UQ, to commence a teaching and research position.
Her research program at UQ uses interdisciplinary approaches incorporating biochemistry, proteomics, molecular and cell biology to understand how individual ubiquitin ligase subunits specifically target their substrates. We focus particularly on understanding the regulation of centrosomes, microtubules and mitochondria.
Corrupting the regulatory pathways that coordinate these organelles can have major health consequences and is the driving force behind many diseases, including cancers and neurodegenerative disorders.