Program

Click on the buttons below to view the schedule for each day.

To view the details of each session, click on, or hover cursor on, headings.

All sessions will be held in the Belmore Room at the Novotel, North Wollongong.

All lunches and morning/afternoon teas will be served in the Keira/Kembla Room.

Chair

Professor Mark Wilson, University of Wollongong, AUS

Invited international speaker

Professor Christopher Dobson, University of Cambridge, UK
The amyloid state of proteins and its significance to human disease

Invited national speaker

Dr Victor Anggono , University of Queensland, AUS
The regulation of AMPA receptor trafficking by protein ubiquitination and its implication in Alzheimer's disease

Speakers selected from abstracts

Dr Yann Gambin, University of New South Wales, AUS
Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence

Dr Priyanka Joshi, University of Cambridge, UK
Exploring the missing link between metabolite homeostasis and protein homeostasis

Associate Professor Vicky Lawson, University of Melbourne, AUS
Immunocytochemical evaluation of alpha-synuclein and dopamine transporter expression in cells of the myenteric plexus of MPTP induced Parkinson’s disease mice

12:00 PM - 1:30 PM

Chair

John Carver, Australian National University, AUS

Invited international speaker

Associate Professor Justin Benesch, University of Oxford, UK
Chaperoning mechanical muscle proteins: a new paradigm for small heat shock protein function

Invited national speaker

Dr Archa Fox, University of Western Australia, AUS
Enhancing the spatiotemporal sub-nuclear sequestration of RNA binding proteins by manipulating paraspeckle size

Speakers selected from abstracts

Dr James Brown, University of New South Wales, AUS
Determining the influence of Lewy body components on the aggregation of α-synuclein

Dr Yuning Hong, La Trobe University, AUS
Monitoring early-stage protein aggregation by an aggregation-induced emission fluorogen

Associate Professor Shelli McAlpine, University of New South Wales, AUS
Designing chemical tools that target heat shock proteins

Dr Chi Le Pham, University of Sydney, AUS
How fungi use self-assembling proteins to control the infection interface

Chair

Dr Amy Wyatt, Flinders University, AUS

Invited international speaker

Professor Irina Buhimschi, Ohio State University College of Medicine, USA
Preeclampsia as a model of impaired proteostasis in pregnancy

Invited national speaker

Associate Professor Danny Hatters, University of Melbourne, AUS
Measuring proteostasis quantitatively

Speakers selected from abstracts

Dr Michael Friedrich, University of Wollongong, AUS
Non-disulfide crosslinking of long-lived proteins: Implications in proteostasis and disease

Dr Francesco Simone Ruggeri, University of Cambridge, UK
Unravelling amyloid formation and structure at single aggregate scale by infrared nanospectroscopy

Dr Alysia Vrailas-Mortimer, Illinois State University, USA,
Proteomic analysis of p38 MAPK longevity reveals regulation of age-dependent disease proteins

Dr Michael Griffin, University of Melbourne, AUS
Lipids exert complex effects on multiple stages of apolipoprotein C-II amyloid formation and alter the structure of mature fibrils

8:30 AM - 10:30 AM

Chair

Dr Lezanne Ooi, University of Wollongong, AUS

Invited international speaker

Professor Alfred Goldberg, Harvard Medical School, USA
Regulation of proteasome function and degradation of misfolded proteins in normal and disease states

Invited national speaker

Dr Loretta Dorstyn, University of South Australia, AUS
Caspase-2 protease activity is required to limit aneuploidy and tumourigenesis

Speakers selected from abstracts

Dr Albert Lee, Macquarie University, AUS
Mutations to a new ALS/FTD gene, CCNF, uncovers new mechanisms of Lys48-ubiquitylation regulation by the Skp-Cul-F-Box(Cyclin F) (SCF(CyclinF)) E3 ligase complex

Dr Justine Mintern, University of Melbourne, AUS
Decoding ubiquitin events that shape immunity

Dr Darren Saunders, University of New South Wales, AUS
Defining the ubiquitin-modified proteome in development and disease

Natalie Farrawell, University of Wollongong, AUS
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

Chair

Dr Justin Yerbury, University of Wollongong, AUS

Invited international speaker

Professor Richard Morimoto, Northwestern University, USA
Proteostasis networks and the heat shock response in aging and neurodegenerative disease

Speakers selected from abstracts

Dr Claire Stevens, University of Wollongong, AUS
Increased phosphorylated and insoluble tau in motor neuron disease

Dr Karen Stroobants, University of Cambridge, UK
Mitochondrial membrane protein misfolding and aggregation in S. cerevisiae as model system

Dr Natalie Spillman, University of Melbourne, AUS
A comparative investigation of proteasome inhibition by dihydroartemisinin in malaria parasites and mammalian cancer lines

Dr Prajwal Ciryam, Columbia University, USA
Tracking proteome metastability in conformational disorders inside and outside the nervous system

Dr Angela Laird, Macquarie University, AUS
Drugs that induce autophagy are protective for a transgenic zebrafish model of neurodegenerative disease

1:00 PM - 4:30 PM

Special event

A Conversation with Professor Christopher Dobson

2:30pm – 3:30pm

Belmore Room

4:30 PM - 6:30 PM

Presentations

Sonia Sanz Muñoz, University of Wollongong, AUS
Extracellular Apolipoprotein E 25 kDa N-terminal fragment formation is regulated by high-temperature requirement serine peptidase A1

Aidan Grosas, Australian National University, AUS
Macromolecular crowding of alphaB-crystallin results in kinetically distinct amorphous and fibrillar aggregation

Andre Leitao, University of New South Wales, AUS
On the hunt for modulators of alpha-synuclein's aggregation: single molecule techniques to deconstruct the Lewy bodies in Parkinson's disease

Britt Berning, Macquarie University, AUS
Fragmentation of golgi apparatus occurs early in disease in a mouse model of Amyotrophic Lateral Sclerosis

Rebecca San Gil, University of Wollongong, AUS
Can pathogenic protein aggregation induce a heat shock response in neuron-like cells?

Emily Selig, University of Melbourne, AUS
Novel evidence that the alpha-crystallin domain of small heat-shock proteins binds the ends of amyloid fibrils

Giulia Vecchi, University of Cambridge, UK
The interactome of misfolded oligomers with proteins investigated with a proteomic approach

Jessica Bridgford, University of Melbourne, AUS
Proteostasis in the malaria parasite Plasmodium falciparum

Monique Bax, University of Wollongong, AUS
Ubiquitin signalling is important in induced pluripotent stem cell survival and iPSC-derived motor neuron differentiation

Sunyuan Zhang, University of Melbourne, AUS
Physical characterization of ataxin-1[85Q] nuclear bodies

8:30 AM - 10:00 AM

Chair

Associate Professor Heath Ecroyd, University of Wollongong, AUS

Invited international speaker

Professor Linda Greensmith, University College London, UK

Title to be confirmed.

Speakers selected from abstracts

Dr Martin Engel, University of Wollongong, AUS
Novel nitroxides protect against oxidative stress-induced apoptosis and cytotoxicity in a patient-derived in vitro model of Alzheimer’s disease

Dr Benedetta Mannini, University of Cambridge, UK
The inflammatory response and the structure-activity relationship in aberrant protein oligomers

Dr Mourad Tayebi, Western Sydney University, AUS
Aggregation of metastable serum proteins in response to inflammation

Professor Leann Tilley, University of Melbourne, AUS
Target validation and identification of novel boronate inhibitors of P. falciparum proteasome

Dr Agata Rekas, ANSTO, AUS
Studies of protein misfolding and chaperoning using neutron scattering

Chair

Dr Kara Perrow, University of Wollongong, AUS

Invited international speaker

Professor William Balch, The Scripps Research Institute, USA
Exploring proteostasis through variation landscapes

Invited national speaker

Associate Professor Mary Bebawy, University of Technology, AUS
Drug pumps and vesicles confer a complex resistance phenotype in cancer

Speakers selected from abstracts

Dr Adam Walker, Macquarie University, AUS
Identifying molecular drivers of TDP-43 proteinopathy using neuronal and mouse models of ALS/FTD

Dr Emma Sierecki, University of New South Wales, AUS
Discovery of a new prion-like behaviour linked with infantile epilepsy

Professor Roger Truscott, University of Wollongong, AUS
Long-lived proteins and their degradation. Is this the “elephant in the room” that enables us to understand the genesis of many age-related human diseases?

Dr Prachi Mehta, Macquarie University, AUS
Apolipoprotein D (ApoD) as a potential new blood protein biomarker for motor neuron disease (MND)

12.30 PM - 1.30PM

Chair

Professor Brett Garner, University of Wollongong, AUS

Invited international speakers

Professor Michele Vendruscolo, University of Cambridge, UK
Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

Dr Natura MyekuColumbia University, USA
Receptor-mediated proteasome activation to stop trans-synaptic propagation of tauopathy

Invited national speaker

Associate Professor Julie Atkin, Macquarie University, AUS
Novel therapeutic strategies based on proteostasis in Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease (MND)

Speakers selected from abstracts

Mauricio Cabral-da-Silva, University of Wollongong, AUS
iPSC-derived microglia (iMG) as a tool for investigating sporadic Alzheimer’s disease

Shu Yang, Macquarie University, AUS
Proteostasis abnormality in ALS patient skin fibroblasts