8:30 AM - 10:30 AM

Session 4: Protein degradation

Chair

Dr Lezanne Ooi, University of Wollongong, AUS

Invited international speaker

Professor Alfred Goldberg, Harvard Medical School, USA
Regulation of proteasome function and degradation of misfolded proteins in normal and disease states

Invited national speaker

Dr Loretta Dorstyn, University of South Australia, AUS
Caspase-2 protease activity is required to limit aneuploidy and tumourigenesis

Speakers selected from abstracts

Dr Albert Lee, Macquarie University, AUS
Mutations to a new ALS/FTD gene, CCNF, uncovers new mechanisms of Lys48-ubiquitylation regulation by the Skp-Cul-F-Box(Cyclin F) (SCF(CyclinF)) E3 ligase complex

Dr Justine Mintern, University of Melbourne, AUS
Decoding ubiquitin events that shape immunity

Dr Darren Saunders, University of New South Wales, AUS
Defining the ubiquitin-modified proteome in development and disease

Natalie Farrawell, University of Wollongong, AUS
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS